Platelet Rich Plasma(PRP)

Platelet Rich Plasma

What are Platelet Rich Plasma?

Platelet-rich plasma (Abbreviation: PRP) is blood plasma that has been enriched with platelets. As a concentrated source of autologous platelets, PRP contains (and releases through degranulation) several different growth factors and other cytokines that stimulate healing of bone and soft tissue.

Platelets are a specialized type of blood cell involved in injury healing. Platelets also contain large reservoirs of natural growth factors that are essential for the cell recruitment and multiplication involved in wound healing. The normal concentration of platelets circulating in our blood is 200,000 per microliter. Current evidence suggests that platelet count in Platelet Rich Plasma should be near or exceed 1,000,000 platelets per microliter which is a concentration of 5x. PRP is made in the office using a centrifuge that separates the blood components and allows us to discard unwanted elements from the blood and to keep the platelets, growth factors, cytokines, and plasma that are used for PRP. The centrifuge takes less than 10 minutes to concentrate the platelets after blood is drawn from the patient.

What happens after the PRP injection in the office?

Most patients will have some soreness after the injection that should decrease rapidly. Patients should not take aspirin or other NSAID medications after the procedure because they may block the effect of PRP. Patients can use Tylenol and other pain medications that don’t block the inflammatory process. Patients should refrain from significant physical activity or sports activities for a week after the procedure. Patients are re-evaluated often after the procedure to make sure their recovery process is proceeding according to plan.

  • Some of the growth and healing factors found in PRP include:
  • Platelet Derived Growth Factor (PDGF)
  • Fibroblast Growth Factor (FGF)
  • Vascular Endothelial Growth Factor (VEGF)
  • Interleukin 8 (IL-8)
  • Transforming Growth Factor Beta (TGF-b)
  • Insulin like Growth Factor 1, 2 (IGF-1,2)
  • Epidermal Growth Factor (EGF)

PRP is being studied and used for many orthopedic conditions.

 

Tendonitis (Chronic tendonitis or partial-thickness tears)

  • Rotator cuff
  • Biceps
  • Golfers/Tennis elbow
  • Tendonitis around the thigh (Gluteus medius, hamstring, piriformis syndrome)
  • Patellar or quadriceps tendonitis
  • Tendonitis around the ankle (Peroneal, Tibialis posterior)
  • Achilles
  • Plantar fasciitis

Ligament Injury

  • Ulnar collateral ligament injury of the elbow
  • Medial collateral ligament injury of the knee

 

Degenerative Joint Disease

  • Hip osteoarthritis
  • Knee osteoarthritis
  • Ankle osteoarthritis
  • Shoulder osteoarthritis
  • Elbow osteoarthritis
  • Wrist osteoarthritis
  • Symptomatic articular cartilage injury

Fracture Care

  • Delayed union or nonunion fractures